Candidate: Susan J. Lentz
Doctor of Philosophy
A fundamental need exists for aquatic animals in the
biomonitoring of aquatic ecosystems for environmental carcinogens. G.
affinis, a small fish species, is selected for this study due to its
hardiness, non-migratory nature, geographic diversity and ability to
develop tumors. Molecular tools for cellular proliferation and death
are examined for use with G. affinis. Additionally, these tools are
used to investigate the early carcinogenic effects of 2-aminofluorene
and benzidine, both individually and combined, on G. affinis livers.
· A transient increase in cellular death at 4 weeks that decreased at 8 and 12 weeks, some below control levels.
· A substantial increase in cellular proliferation throughout the 4, 8 and 12 exposures above control levels.
· A net increase in cellular growth above control levels.
· Increases in oval cell proliferation, altered foci and tumor development.
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