Candidate: Rebecca C. Scherzer

Degree of: Doctor of Philosophy

Department: Statistics

Title: Testing Procedures for Group Sequential Clinical Trials with Multiple Survival Endpoints

Committee: Dr. Daniel Mihalkot, Chair
Dr. Joseph McKean
Dr. Magdalena Niewiadomksa-Bugaj
Dr. Dror Rom

Date: Tuesday, August 2, 2005 10:00 a.m.- 12:00 p.m.
Alavi Commons, Sixth Floor, Everett Tower

Abstract: This research gives methods for sequential monitoring of survival data in clinical trials with multiple endpoints. We illustrate the use of marginal proportional hazards models and other survival models with various group sequential methods to test multiple survival endpoints at K interim analyses. To adjust for multiplicity at each interim analysis, we consider and extend methods developed by Tang and Geller (1999), Follman, et al. (1994), and others. These methods are motivated, compared and evaluated using survival data from a clinical study and using simulation studies.

Related Topics

Main List of Archives:
Dissertation Defenses

Current Dissertation Defenses