EKKEHARD SINN
Professor and Chair
WMU Department of Chemistry,   Kalamazoo, MI 49008-5413
Phone 269-387-2832       FAX 269-387-2909

BA 1972 (Anthropol&Chinese) U of Sydney
BSc (Physics&Math), MSc (Phys Chem) Sydney
PhD (Inorg Chem) U of New South Wales
        F.R.A.C.I.       CChem       FRSC
  ekk.sinn@wmich.edu        esinn@umr.edu     
                 
•Recent Publications
•More Publications - The Early Days

RESEARCH
Everything in the Chemist's world revolves around the outermost electrons of atoms.
How we pair them or not governs how biomolecules work, what magnetism we get,
and what new kinds of smart materials we can make. Follow a humble inorganic
chemist's path as it touches some of the fascinating possibilities of our world:
ENZYMES
CANCER KILLERS; AND A WARNING SHOT AT OTHER DISEASES
NEW INFORMATION STORAGE DEVICES
NEW KINDS OF LASERS
MOLECULAR MAGNETS
DESIGNER CATALYSTS
MOLECULAR ELECTRONICS
METAL CONTAINING LIQUID CRYSTALS
OTHER NEW MATERIALS
OXYGEN CARRIERS
IRON SEQUESTERERS (SIDEROPHORES) and GRABBERS OF OTHER METAL ATOMS
Measuring bond lengths directly in mixed spin systems without crystallography or NMR
THE AGING PROCESS (before it's too late)
and MORE
Also we'll look at ways we can get it wrong
WHO SAID CHEMISTRY ISN'T INTERESTING!
RECENT SELECTED PUBLICATIONS

312. Synthesis, Characterization, and Reactivity of Iron Trisamidoamine Complexes that undergo both Metal- and Ligand-Centered Oxidative Transformations. Remle Celenligi-Cetin, Patrina Paraskevopolou, Rupam Dinda, Richard J. Staples, Ekkehard Sinn, Nigam P. Rath and Pericles Stavropoulos, Inorg. Chem. Comm., 2008, 47, 1165-1172.

311. Oxidative Ligand Rearrangement due to Incipient Aminyl Radicals in the Oxidation of Iron(II) Species with Dioxygen. Remle Celenligi-Cetin, Patrina Paraskevopolou, Rupam Dinda, Nikolia Lalioti, Yiannis Sanakis, Abdel Monem Rawashdeh, Richard J. Staples, Ekkehard Sinn and Pericles Stavropoulos, European Journal of Inorg. Chem., 2008, 5, 673-677.

310. Copper complexes of henna-sulforaphane conjugates as potent antiproliferative agents against human myeloma KBM-5 cells through blockade of transcription factor NF-KB. K. Shirisha, J. Patole, S. Padhye, E. Sinn, S. Shishodia and B. B. Aggarwal, Letters in Drug Design & Discovery, 2007, 4, 257-262.

309. Copper Conjugates of Nimesulide Schiff Bases Targeting VEGF, COX, and BcI-2 in Pancreatic Cancer Cells. Vinita Ambike, Shreelekha Adsule, Fakhara Ahmed, Zhiwei Wang, Zahra Afrasiabi, Ekkehard Sinn, Fazlul Sarkar and Subhash Padhye, Inorg. Biochem., 2007, 99, 1517-1524.

308. Neutral dimeric copper-sparfloxacin conjugate having butterfly motif with antiproliferative effects agains hormone dependent BT20 breast cancer cell line. Dipti Shingnapurkar, Ray Butcher, Zahra Afrasiabi, Ekkehard Sinn, Fakhara Ahmed, Fazlul Sarkar and Subhash Padhye, Inorg. Chem. Comm., 2007, 10, 459-462.

307. Nickel(II) Complexes of Naphthaquinone Thiosemicarbazone and Semicarbazone: Synthesis, Structure, Spectroscopy and Biological Activity. Zahra Afrasiabi, Ekkehard Sinn, Weisheng Lin, Yinfa Ma, Charles Campana and Subhash Padhye, Inorg. Biochem., 2005, 99, 1526-1531.

306. Antitumor Metallothiosemicarbazonates: Structure and Antitumor Activity of Palladium Complex of Phenanthrenequinone Thiosemicarbazone. Subhash Padhye, Zahra Afrasiabi, Ekkehard Sinn, J Fok, K Mehta, Nigam Rath, D. Deobagakar, Chris E Anson and Annie K Powell, Inorg. Chem., 2005, 44, 1154.

305. Gadolinium Triflate Immobilized in Imidazolium Based Ionic Liquids: a Recyclable Catalyst and Green Solvent for Acetylation of Alcohols and Amines. Ramesh Alleti, Woon Su Oh, Meher Perambuduru, Zahra Afrasiabi, Ekkehard Sinn and V. Prakash Reddy. Green. Chem., 2005, 7, 203.

303. The Cytotoxicity and Mechanisms of 1,2 Naphthoquinone Thiosemicarbazone and Its Metal Derivatives Against MCF-7 Human Breast Cancer Cells. Junan Chen, Y. Huang, Guotao Liu, Zahra Afrasiabi, Ekkehard Sinn, Subhash Padhye and Yinfa Ma, Toxicol. and Appl Pharmacol., 2004, 197, 40.

301. Appended 1,2-naphthoquinones as anticancer agents 1: synthesis, structural, spectral and antitumor activities of ortho-naphthaquinone thiosemicarbazone and its transition metal complexes. Zahra Afrasiabi, Ekkehard Sinn, Junan Chen, Yinfa Ma, Arnold L. Rheingold, Lev N. Zakharov, Nigam Rath and Subhash Padhye. Inorg, Chim. Acta., 2003, 357, 271.

300. Synthesis and Mesogenic Properties of Binuclear Copper (II) Complexes Derived from Salicylaldimine Schiff Bases. Reinhard Paschke, Stefan Liebsch, Carsten Tschierske, Michael A. Oakley and Ekkehard Sinn, Inorg. Chem., 2003, 42, 8230.

299. Structural Study of the Thermal and Photo-chemical Spin States in the Spin Crossover Complex [Fe(phen)2(NCSe)2 ]. Catherine M. McGrath, C. Sangregorio, Jonathan W. M. Seddon, Ekkehard Sinn, Frank E. Sowery, Simon J. Teat, G.B.M. Vaughan and Nigel A. Young, Chemistry: A European Journal, 2003, 9, 5314.

298. Hemiprotonated dafone, a new cationic species. The novel di-dafonium iron(III) complex: [(dafone)2H]+[FeCl4-]. Kulkarni, P.; Padhye, S.; Sinn, E. Inorg. Chem. Comm., 2003, 6, 1129.

297. Transition metal complexes of Phenanthenequinone Thiosemicarbazone as Potential Anticancer Agents: Synthesis, Structure, Spectroscopy, Electrochemistry and in vivo Anticancer Activity Against Human Breast Cancer Cell-line T47D. Zahra Afrasiabi, Ekkehard Sinn. Shreelakha Padhye, Sabari Dutta, Subhash Padhye, Chris Newton, Christopher E. Anson and Annie K. Powell, J. Inorg. Biochem., 2003, 95, 306.

296. Cholic Acid - Carboplatin Compounds (ChAPt) as Models for Specific Drug Delivery. Synthesis of novel carboplatin analogous derivatives and comparison of the cytotoxic properties with corresponding cisplatin compounds. Paschke, R.; Kalbitz, J.; Paetz, C.; Luckner, M.; Mueller, T.; Mueller, H.; Sorkau, E.; Sinn E., J. Inorg. Biochem., 2003, 94, 335.

295. Biomolecules Linked to transition metal complexes New Chances for Chemotherapy. Reinhard Paschke, Christian Paetz, Thomas Mueller, Hans-Joachim Schmoll, Helmut Mueller, Eduard Sorkau and Ekkehard Sinn, Current Medicinal Chemistry, 2003, 10, 1241.

294. Cis Di-oxomolybdenum(VI) Complexes with a Tridentate ONO Donor Ligand; Synthesis, X-ray Crystal Structure, Spectroscopic Properties and Oxotransfer Chemistry. Uday Sandbhor, Subhash Padhye and Ekkehard Sinn, Transition Met. Chem., 2002, 27, 681.

293. New Principles in Metallomesogen Structure-Magnetism Correlations. Stefan Liebsch, Michael A. Oakley, Reinhard Paschke and Ekkehard Sinn, Inorg. Chem. Comm., 2002, 5, 525.

292. Lowering Melting Points in Asymmetrically Substituted Salen-Copper(II) Complexes Exhibiting Mesomorphic Behavior. Structure of the Mesogen Cu(5-hexyloxySalen). Reinhard Paschke, DĀrte Balkow, and Ekkehard Sinn Inorg. Chem., 2002, 41, 1949.

291. Comparative studies on Copper(I) complexes: Synthesis, x-ray crystallography and electrochemical properties of [CuI(dafone)nX] complexes (dafone = 4,5-diaza-fluoren-9-one, X = Br, I, SCN). Prasad Kulkarni, Subhash Padhye, Ekkehard Sinn, Christopher E. Anson and Annie K Powell, Inorg. Chim. Acta, 2002, 332, 167.

290. The First Uranium Based Liquid Crystals. Uranyl Metallomesogens from ß-diketonate and Tropolone Ligands. Stephen Clark, James M Elliott, John R Chipperfield, Peter Styring, Ekkehard Sinn, Inorg. Chem. Comm, 2002, 5, 249.

289. Synthesis, structure, spectroscopy and antitumor activity of hydroxy naphthoquinone thiosemicarbazone and its metal complexes against MCF-7 human breast cancer cell line. D K Saha, S Padhye, E Sinn, C Newton, Indian J. Chem. Sect A-Inorg. Bio-Inorg. Phys. Theor. Anal., 2002, 41, 279.

288. Liquid Crystal Phase Crossover (Columnar — Calamitic) in Polycatenar CuII 5-(3,4-dialkoxybenzylidine)aminotropolonates. James M Elliott, John R Chipperfield, Stephen Clark and Ekkehard Sinn, Inorg. Chem. Comm, 2002, 5, 99.

287. Criteria for Liquid Crystal Formation in 5-Alkoxy-, 5-Alkylamino-, and 5-Alkanoyl-tropolone Complexes of Transition Metals (CuII, ZnII, NiII, CoII, UO2VI, VOIV). The first Uranium Metallomesogen. Crystal Structure of Bis(5-hexadecyloxytropolonato)copper(II). James M. Elliott, John R. Chipperfield, Stephen Clark, Simon J Teat and Ekkehard Sinn Inorg. Chem., 2002, 41, 293. text .

286. Cross-over Phase Behavior (Discotic to Calamitic) in Liquid-crystalline Copper Complexes. Dependence on Length and Position of Alkoxy Chains in new Polycatenar Bis[5-(dialkoxybenzylidine)aminotropolonato]copper(II) Complexes. James M Elliott, John R Chipperfield, Stephen Clark and Ekkehard Sinn, Inorg. Chem., 2001, 40, 6390. graphic . text .

285. Neutral metal complex in an ionic pocket: synthesis, physicochemical properties and X-ray structure of a copper(II) complex containing neutral as well as cationic dafone ligands and dafonium perchlorate. Prasad Kulkarni, Subhash Padhye and Ekkehard Sinn, Inorg. Chim. Acta, 2001, 319, 193.

284. Tuning up Superoxide Dismutase Activity of Copper Complex of Salicylaldehyde Semicarbazone by Heterocyclic Bases Pyridine and N-methylimidazole. J Patole, S Dutta, S Padhye, and E Sinn, Inorg. Chim. Acta, 2001, 318, 2435.

283. Copper-Catalysed Asymmetric 1,4-Addition of Organozinc Compounds to Linear Aliphatic Enones Using 2,2'-Dihydroxy-3,3'-Dithioether Derivatives of 1,1'-Binaphthalene. Christoph Börner, Michael R Dennis, Ekkehard Sinn, Simon Woodward, Eur. J. Org. Chem., 2001, 2435.

282. Modeling of the Ni-Fe-center of Ni-CO-dehydrogenase by Nickel Complexes with Thiazaligands. V.V. Pavlishchuk, S.V. Kolotilov, A.W. Addison, M.J. Prushan, R.J. Butcher, E. Sinn, Ukr. Biokhim. Zh., 2001, 73, 91.

281. Metal Complexes as Anticancer Agents. 2. Synthesis, Spectroscopy, Magnetism, Electrochemistry, X-ray Crystal Structure and Antimelanomal Activity of the Copper(II) Complex of 5-amino-1-tolylimidazole-4-carboxylate in B16F10 Mouse Melanoma Cells. M Collins, E Ewing, G Mackenzie, E Sinn, U Sandbhor, S Padhye, G S Padhye, Inorg. Chem. Comm., 2000, 3, 453.

280. Nickel(II), Nickel(I), and Nickel(0) Complexes with 1,8-Bis(2'-pyridyl)-3,6-dithiaoctane. V V Pavlishchuk, S V Kolotilov, A W Addison, E Sinn, M J Prushan, Russian J. Inorg. Chem., 2000, 45, 544.

279. Komplekci Hikelya(II), Hikelya(I) I Hikelya(0) S 1,8-bis(2'-piridil)-3,6-ditiaoktanom. V V Pavlishchuk, S V Kolotilov, A W Addison, E Sinn, M J Prushan, Z. Heorg. Khim., 2000, 45, 615.

278. Nickel(II) complexes with Dithiadiiminoamine and dithiabis(thiosemicarbazone) ligands. V V Pavlishchuk, S V Kolotilov, A W Addison, R J Butcher, E Sinn, J. Chem. Soc., Dalton Trans., 2000, 335. text .

277. Hormone Anchored Metal Complexes. 1. Synthesis, Structure, Spectroscopy and In Vitro Antitumor Activity of Testosterone Acetate Thiosemicarbazone and its Metal Complexes. A Murgukar, B Unnikrishnan, S Padhye, R Bhonde, S Teat, E Triantafillou, E Sinn, Metal-Based Drugs, 1999, 6,177.

276. Direct Measurement of the High-spin and Low-spin M-L Bond Lengths and the Spin State Population in Mixed Spin Systems: an Fe K-edge XAFS Study of Iron(III) Dithiocarbamate Complexes. C M McGrath, C J O'Connor, C Sangregorio, J M W Seddon, E Sinn, F E Sowrey, N A Young, Inorg. Chem. Comm., 1999, 2,536.

274. New Chiral Ligands Incorporating useful functionality: Racemic Palladium(II) Dichloride Complexes of Bidentate Ligands Containing Two Non-coordinated Ester Groups and Three Chrial Centers of Known Relative Stereochemistry. T S Billson, J D Crane, D Foster, C S L Russel, E Sinn, S J Teat, N A Young, Inorg. Chem. Comm., 1999, 2,476.

271. 1,4,8,11-tetrakis(4-ferrocenyl-3-azabutyl)-1,4,8,11-tetraazacyclotetradecane as a ferrocene-functionalised polyammonium receptor for electrochemical anion sensing. Lloris, J.M.; Martinez-Manez, R.; Padilla-Tosta, M. E.; Pardo, T.; Soto, J.; Garcia-Espana, E.; Ramirez, J.A.; Burguete, M.Y.; Luis, S.V.; Sinn, E., J. Chem. Soc., Dalton Trans., 1999, 1779.

268. An insight into ion-transport by calixarenes; the structure of the dipotassium complex of p-tert-butylcalix[8]arene crystallised from a protogenic, coordinating solvent [ethanol/diethylcarbonate (10:1)]. N P Clague, W Clegg, S J Coles, J D Crane, J D Moreton, E Sinn, S J Teat, N A Young, J. Chem. Soc., Chem. Comm., 1999, 379.

261. New Metallomesogen core. New Copper Complexes with Calamitic Mesophases using Tropolone based Ligands. Crystal Structure of Bis(5-octyloxytropolone)copper. Chipperfield, J.R.; Clark, S.; Elliott, J.; Sinn, E., J. Chem. Soc., Chem. Commun., 1998, 195.

260. The Effect of Low Molecular Weight Organosiloxane Substituents on Mesophase Formation and Structure in Non-Symmetric Nickel(II) Complexes. I M Saez, G H Mehl, E Sinn, P Styring, J. Organomet. Chem., 1998, 551, 299.

255. Catalytic Conjugate Addition Promoted by the Copper(I)-Monothiobinaphthol System. Part 2. Optimal Ligand Synthesis and Initial Catalytic Results. S M Azad, S M W Bennett, S M Brown, J Green, E Sinn, C M Topping, S Woodward, J. Chem. Soc., Perkin Trans. 1, 1997, 687.

250. The First Oxovanadium(V)-thiolate Complex. [VO(SCH2 CH2 )3 N ]. K K Nanda, A W Addison, E Sinn, Inorg. Chem., 1996, 35, 1.

239. Peroxo aminopolycarboxylato vanadate(V) of an unusually low toxicity: synthesis and structure of the very stable K[VO(O2)(C6H6NO6)].2H2O. C Djordjevic, P L Wilkins, E Sinn, R J Butcher, Inorg. Chim. Acta 1995 230 241.



                                            "UNDER CONSTRUXION"