- Research Interests
- On-Going Research Projects
- Research Collaborators
- Peer Reviewed Research Journal Publications
- Conference and Proceedings
- Teaching Experience
- Academic Appointments
- Non-Academic Appointments
- Other Roles
- Academic Achievement Awards
- Prototypes Development and Technology Commercialization
- Postdoc., Chemical Engineering, Rutgers University, USA, 2009.
- Ph.D., Chemical Engineering, New Mexico State University, USA, 2006.
- MS., Chemical Engineering, New Mexico State University, USA, 2004.
- MBA., Technology Commercialization, New Mexico State University, USA, 2005.
Aerosol production of nanoparticles, crystal growth, nanoparticle synthesis of bimetallic and core-and-shell nanoparticles, carbon thin films, carbon supported nanoparticles, functional nanomaterials and advanced devices, pharmaceutical formulations, droplet dynamics, shear and electrostatic effects of micronized powders, material science, microstructure investigation through structure performance evaluations, particle dynamics, pharmaceutical formulations, powder flow, drug release and development, tablet manufacturing and characterization, electrostatics, phase transitions on particles, studies on molecular reorganizations and the subsequent characterization of the value-added engineered products related to particle and powder technology.
Nanoparticle Engineering for Multi-scale Pharmaceutical Process Systems
Nanoparticle Engineering for Multi-Scale Pharmaceutical Process Systems (NEMPPS) is focused on testing the hypothesis that structural geometries of organic nanocoatings at interfaces of microscale pharmaceutical materials tailor macroscale bulk properties. The project aims to a) discover the methodology and science behind creating unique core (magnesium stearate)-and-shell (colloidal silica) organic nanostructures (< 20 nm) at low temperatures b) introduce them at the interfaces of microscale particles through nanocoating c) quantify and characterize the nanocoatings in terms of nanocoating percent area and uniformity as a function of process variables across scales; and d) conduct basic scientific research on contact mechanisms and evolve these mechanisms into engineered solutions reflecting geometric interactions on a macroscale in bulk pharmaceutical manufacturing.
Surface Modified Drug Particles with Hydrophilic Nano Biopolymer
The goal of this project is to minimize the use of expensive binders and improve the robustness of granulation process (reduce granulation time) in pharmaceutical manufacturing. Pharmaceutical industry faces frequent powder granulation and processing failures due to processes that are not very robust. These methods of granulation often result in extensive batch failures, high number of unit operations and increased costs. There is an imminent need to improve granulation robustness for enhanced pharmaceutical manufacturability. Conventional processing methodologies do not lead to a robust process due to multiple dependencies that are sometimes difficult to control. These dependencies include excipient and bulk powder properties, excipient functionality, process parameters and formulation composition. The elimination of binders in granulation process phenomenally transforms the overall pharmaceutical manufacturing process in terms of improved robustness and huge cost savings. This project is the first to fully consider the multi-scale effects across scales.
Hydrophobic and Hydrophilic Forces on PVD Coated Organic Crystals
In this research work, we investigate the hydrophilic and hydrophobic forces acting on organic crystal planes and understand the interaction of functional groups with additive molecular nanolayers on crystal surfaces. we address this issue by investigating the hydrophobic and hydrophilic functional groups’ interaction with chemical nature of both API and excipient (lactose) as well as interfacial nanolayers of colloidal silica (CS), a commonly known glidant in pharmaceutical manufacturing. Here we attempt to demonstrate that hydrophobic and hydrophilic interaction forces vary with nanocoated layers, exciopient lactose and active drug APAP. The results and findings from this study are important to understand the interaction forces of pharmaceutical materials with hydrophobic and hydrophilic additives and their mixing order during powder flow and mixing. AFM studies with respect to mixing order of nano additives on organic crystals is a complex phenomenon which is of interest to many pharmaceutical manufacturing industries involving additives and drug materials.
Powder Flow Characteristics
A powder flow measuring device running with a load cell device and a camera is used in Dr Pingali’s lab to measure the flow characteristics of pharmaceutical formulations, dilation, electrstatics and mixing patterns. The unit consists of a drum backlighted with LED and a digital camera. Image processing of the shadow on the end of the drum is done by the dilation program. Flow characteristics of various formulations, their consolidation states of dilation with respect to mechanical shear, size and component fraction, geometry and scale of the processing equipment are measured. Dr Pingali developed this device while working at Rutgers University in Prof. Fernando Muzzio’s lab. Dr Pingali is grateful to Dr Muzzio for allowing the device to be brought to Western Michigan University for further improvement and development of the next phase.
Microgravity Effects on Pharmaceutical Granular Flow Dynamics
The project is unique in studying the particulate/granular flow dynamics by isolating the linear forces and minimizing the contributions to electrostatic charge and static friction in powder particles. Investigating the electrostatic phenomena on macroscopic bulk processing of powders, emerging from the interaction of multi-scale granular constituent materials in pharmaceutical materials under micro-gravity is unique. The focus is on investigating fundamental science of particle friction and electrostatics behind the transport, mixing and interaction of multi-scale (nano, meso, micro and macro) granular material (pharmaceutical powder) under micro-gravity environment.
- Ayappa, Ganapathy
o Indian Institute of Science, Bangalore, Karnataka, 560012, India.
- Chi Hwa, Wang
o National University of Singapore, Singapore, 117585.
- Lieu, William
o Western Michigan University, MI 49008.
- Lueptow, Richard
o Northwestern University, Evanston, IL 60201.
- Matsusaka, Shuji
o Kyoto University, Nishikyo-ku, Kyoto 615-8510, Japan.
- Mendez, Rafael
o University of Puerto Rico, Mayaguez, 00681.
- Mieler, Jennifer Kang
o Illinois Institute of Technology, Chicago, IL 60616.
- Rajh, Tijana
o Argonne National Laboratories, Argonne, IL 60439.
- Ramachandran, Rohit
o Rutgers University, Piscataway, NJ 08854.
- Rozhkova, Elena
o Argonne National Laboratories, Argonne, IL 60439.
- Tichauer, Kenneth
o Illinois Institute of Technology, Chicago, IL 60616.
- Bristol Myer Squibb, New Brunswick, NJ, 08901.
- Genentech Inc, San Francisco, CA, 94080.
- Perrigo Company, Allegan, MI 49010.
- Abbvie Inc, North Chicago, IL.
- Speciality Pharmaceutical Sciences, Little Rock, AR 72205.
- Overwatch Development Group, Naperville, IL 60563.
- Pingali, K.C., Rockstraw, D., Deng, S. Silver nanoparticles from ultrasonic spray pyrolysis of aqueous silver nitrate solution. Journal of Aerosol Science and Technology, 2005, 39: 1010-1014.
- Pingali. K.C.; Deng, S. and Rockstraw. D. A. Synthesis of Carbon Nanoparticle Thin Film with Spray Pyrolysis. New Mexico J. of Sci., 2006, 44: 149-163.
- Pingali. K.C.; Deng, S. and Rockstraw. D. A. Deposition of Ru-Ni-S Nanoparticles on Carbon by Spray-Pyrolysis: Effects of Solvent. Current Nanoscience, 2007, 3: 215-221.
- Pingali, K.C., Deng, S., Rockstraw, D. Direct synthesis of Ru-Ni nanoparticles with core and shell structure. (2007). Chem. Eng. Comm., 2007, 194: 780-786.
- Pingali. K.C.; Deng, S. and Rockstraw. D. A. "Ammonia Effect on Size Reduction of Nanoparticles Synthesized in a Spray Pyrolysis Process," Research Letters in Nanotechnology, 2008, Volume 2008, Article ID 756843, 4 pages.
- Pingali, K.C., Deng, S., Rockstraw, D. Synthesis and thermal stability of carbon supported and carbon coated Ru-Ni core-and-shell nanoparticles. Powder Technology, 2008, 187, 19–26.
- Deng S., Pingali KC., Rockstraw, D.A. Synthesis of Ru-Ni Core-Shell Nanoparticles for Sensor Applications. IEEE Sensors Journal: Nanosensors for Defense and Security, 2008, 8(6): 730-734.
- Pingali, K.C., Deng, S., Rockstraw, D. Direct synthesis of Ru–Ni core-and-shell nanoparticles by spray-pyrolysis: Effects of temperature and precursor constituent ratio. Powder Technology, 2008, 183 282-289.
- Pingali, K.C., Deng, S., Rockstraw, D. Synthesis of nanotubes and nanowires by spray pyrolysis. (2009). Journal of Sensors. 2009, Volume 2009, Article ID 683280, 6 pages.
- Pingali KC, Muzzio FJ, Shinbrot T. An observed correlation between flow and electrical properties of pharmaceutical blends. Powder Technology. 2009, 192(2): 157-165.
- Pingali KC, Shinbrot T, Muzzio FJ. Use of a static eliminator to improve powder flow. International Journal of Pharmaceutics. 2009, 369(1-2): 2-4.
- Pingali KC, Kostas S, Muzzio FJ. Practical Methods for Improving Flow Properties of Active Pharmaceutical Ingredients. Drug Development and Industrial Pharmacy. 2009, 35(12): 1460-1469.
- Pingali KC, Tomassonne, S.M., Muzzio FJ. Effect of shear and electrical properties on flow characteristics of pharmaceutical blends. Journal of AIChE. 2010, 56(3): 570 – 583.
- Pingali KC, Mendez, R., Lewis, D., Michniak, B., Muzzio, F.J. Evaluation of strain induced hydrophobicity of pharmaceutical blends and its effect on drug release rate under multiple compression conditions. Drug Development and Industrial Pharmacy, 2011, 37(4): 428-435.
- Pingali KC, Mendez, R., Lewis, D., Michniak, B., Muzzio, F.J. Mixing order of silica and magnesium stearate – Influence on powder and tablet properties. International Journal of Pharmaceutics, 2011, 409: 269-277.
- Pingali, KC, Shinbrot T., Cuitino, A., Muzzio, FJ., Garfunkel, E., Mann, AB. AFM study of hydrophilicity on acetaminophen crystals. International Journal of Pharmaceutics, 2012, 438 (1): 184 – 190.
- Llusa, M., Muzzio, FM., Pingali KC. Method to study the effect of blend flowability on the homogeneity of acetaminophen. Drug Development and Industrial Pharmacy, 2013, 39(2):252 – 8.
- Pingali KC, Mendez, R. Nanosized smeared particles formed during mixing affecting microscopic behavior of pharmaceutical formulations. Chemical Engineering and Process Techniques, 2013, 1(3): 1016.
- Pingali KC, Mendez, R. Nanosmearing due to process shear – Influence on powder and tablet properties. Advanced Powder Technology, 2014, 25(3): 952-959.
- Pingali KC, Mendez, R. Physicochemical behavior of pharmaceutical particles and distribution of additives in tablets due to process shear and lubricant composition. Powder Technology, 2014, 268: 1 – 8.
- Pingali KC, Mendez R. Assessing distribution of nanosmears due to mutual interaction of additives in high shear mixing of pharmaceutical blends. Chemical Engineering and Processing, 2014, 85: 248-255.
- Pingali KC. Consolidated states of dilation in granular material: Experimental investigation and comparison of rheological properties. Advanced Powder Technology, 2015, 26(3): 887-893.
- Pingali KC, Tracy B, Brynes B. Sensing electrostatic charge generation during granular flow of pharmaceutical powders in a flow tester, Journal of Pharmaceutical Innovation, 2016, 11(3): 179–188.
- Pingali KC, Krishnan A, Rajh T, Rozhkova E. Functional groups interaction on PVD coated organic crystals, Langmuir, 2016, (Submitted).
- Chatarla S, Rajh T, Rozhkova E, Pingali KC. Nanosmearing architechture of quantified hydrophilic and hydrophobic groups, Journal of Materials Chemistry, 2016, (Submitted).
CP-1 Pingali, K.C., Deng, S., Rockstraw, D. Direct synthesis of ru-ni nanoparticles with core-and-shell structure. AIChE Annual Symposium, November 2005, Cincinnati.
CP-2 Pingali, K.C., Deng, S., Rockstraw, D. Effect of ammonium nitrate in size reduction for particles of silver, nickel and ruthenium. AIChE Symposium, November 2005, Cincinnati.
CP-3 Pingali, K.C., Deng, S., Rockstraw, D. Synthesis of nanoparticles and nanocatalyst by spray pyrolysis. Graduate Research Art Symposium, April 2006, New Mexico State University.
CP-4 Pingali, K.C., Deng, S., Rockstraw, D. Formation of Ru-Ni core-shell nanoparticles by flash pyrolysis and the effect of temperature and constituent ratio in the precursor: Fourteenth International Conference on Composites / Nano Engineering (ICCE 14), July 2006, Boulder, Colorado.
CP-5 Kalyana C. Pingali, Shuguang Deng, David A. Rockstraw. Synthesis of core-shell nanoparticles and mathematical modeling of exponential relation of particle size variation with precursor concentration. AIChE Conference, November 2006, San Francisco.
CP-6 Pingali KC, Muzzio FJ, Shinbrot T, Tomassone MS. Relation between flow and electrical properties of pharmaceutical blends. Industrial Advisory Board, Engineering Research Center Conference, May 2007, Purdue University, West Lafayette, IN.
CP-7 Pingali KC, Muzzio FJ, Shinbrot T. Effect of shear and charge density on the relation between flow and electrical properties of multiple formulations of pharmaceutical blends. Industrial Advisory Board, Engineering Research Center Conference, May 2007, Purdue University, West Lafayette, IN.
CP-8 Pingali KC, Muzzio FJ, Shinbrot T. Effect of additives in minimizing electrostatic effects of pharmaceutical powders and blends. Industrial Advisory Board, Engineering Research Center Conference, May 2007, Purdue University, West Lafayette, IN.
CP-9 Pingali KC, Muzzio FJ, Shinbrot T. Flow and electrical properties of pharmaceutical blends – Effect of additives in minimizing electrostatics. Industrial Advisory Board, Engineering Research Center Conference, September 2007. Rutgers University, Piscatway, NJ.
CP-10 Pingali KC, Muzzio FJ. Powder flow characteristics of real drugs – Effect of additives and glidants. Industrial Advisory Board, Engineering Research Center Conference, September 2007. Rutgers University, Piscatway, NJ.
CP-11 Marcos Llusa, Fernando Muzzio, Kalyana Pingali. The effects of material and processing variables on the properties of formulations. AIChE Conference, Nov 2007, Salt Lake City.
CP-12 Pingali KC, Shinbrot T, Muzzio FJ. Understanding optimizing flow properties of pharma blends. NSF - Engineering Research Center Conference, January 2008, Puerto Rico.
CP-13 Pingali KC, Shinbrot T, Muzzio FJ. Shear and electrostatic effects on powders – influence of glidants, excipients and lubricants on powder flow. Industrial Advisory Board, Engineering Research Center Conference, May 2008, Purdue University, West Lafayette, IN.
CP-14 Pingali KC, Muzzio FJ. Tablet weight variability of multiple pharmaceutical blends and its relation to shear, electrostatics and powder flow. Industrial Advisory Board, Engineering Research Center Conference, May 2008, Purdue University, West Lafayette, IN.
CP-15 Pingali KC, Muzzio FJ. Powder flow properties and its relation to shear and electrostatics – Influence of excipients, glidants and lubricants. Industrial Advisory Board, Engineering Research Center Conference, September 2008, Rutgers University, Piscatway, NJ.
CP-16 Pingali KC, Muzzio FJ. Shear Effects On Electrostatics, Flow properties and tablet weight variability prepared from multiple pharmaceutical blends. Industrial Advisory Board, Engineering Research Center Conference, September 2008, Rutgers University, Piscatway, NJ.
CP-17 Kalyana Pingali, Wondwossen T. Anbessie, Mehul Alatar, Bozena Michniak-Kohn, Fernando J. Muzzio, Product testing and performance evaluation – Flow and electrostatics of powders and correlation to tablet weight variability. Engineering Research Center Conference, September 2008, Rutgers University, Piscatway, NJ.
CP-18 Alisa Vasilenko, Kalyana Pingali, Fernando J. Muzzio. Shear and composition effects on the flow and electrostatic properties of pharmaceutical powders. AIChE Conference, Nov 2008, Philadelphia, PA.
CP-19 Pingali KC, Kostas S, Muzzio FJ. Practical methods for improving flow properties of active pharmaceutical ingredients. AIChE Conference, Nov 2008, Philadelphia, PA.
CP-20 Pingali KC, Shinbrot T, Muzzio FJ. An observed correlation between flow and electrical properties of pharmaceutical blends. AIChE Conference, Nov 2008, Philadelphia, PA.
CP-21 Pingali, K.C., Mendez, R., Lewis, D., Michniak, B., Muzzio, F.J. Mixing order of flowing agents – influence on powder and tablet properties. NSF – Engineering Research Center Conference, April 2009, Rutgers University, Piscatway, NJ.
CP-22 Pingali, K.C., Mendez, R., Lewis, D., Michniak, B., Muzzio, F.J. Influence of shear on powder hydrophobicity, tablet compression and dissolution. NSF – Engineering Research Center Conference, April 2009, Rutgers University, Piscatway, NJ.
CP-23 Pingali, K.C., Mendez, R., Lewis, D., Michniak, B., Muzzio, F.J. Investigation of drug release profiles – Tablet and powder characterization. Industrial Advisory Board – Engineering Research Center Conference, June 2009, New Jersey Institute of Technology, Newark, NJ.
CP-24 Zhixin ZongPeter L. WildfongLee E. KirschAditya M. KaushalEric J. MunsonRaj SuryanarayananDewey H. BarichKalyana PingaliFernando J. MuzzioDefne Kayrak-TalaySalil D. DesaiIra Shea Buckner, The development of methods to link design space models to product stability, AIChE Conference, Nov 2009, Tennessee.
CP-25 Pingali KC, Tomassonne, S.M., Muzzio FJ. Effects of shear and electrical characteristics on flow properties of pharmaceutical blends. AIChE Conference, Nov 2009, Tennessee.
CP-26 Pingali, K.C., Mendez, R., Lewis, D., Michniak, B., Muzzio, F.J. Evaluation of shear induced hydrophobicity and drug release. AIChE Conference, Nov 2009, Tennessee.
CP-27 Pingali, K.C., Mendez, R., Cuitino A, Muzzio FJ. Spatial positions of organic positions due to thin film nanosmearing under shear environment. AIChE Conference, Nov 2010, Salt Lake City.
CP-28 Pingali, K.C., Muzzio, F.J. Evaluation of shear induced material response on pharmaceutical powders and its influence on product performance. Industrial Advisory Board Workshop – Engineering Research Center Conference, June 2009, New Jersey Institute of Technology, Newark, NJ.
CP-29 Pingali, K.C., Shinbrot, T., Muzzio, F.J., Cuitino, A., Parikh, H., Mann, A., Relationship between material properties and structure of nanocoated organic crystals. AIChE Conference, Oct 2011, Minneapolis.
CP-30 Pingali, K.C., Design and development of an unconsolidated powder flow tester. 5th Asian Particle Technology Symposium, July 2 – 5 2012, Singapore.
CP-31 Pingali, K.C., Particle interaction and adhesion forces due to thin film nanolayers – Influence on drug release rate. 5th Asian Particle Technology Symposium, July 2 – 5 2012, Singapore.
CP-32 Kick, C., Voon, X.E., Pingali, K.C. Nanostructure of individual grains affecting movement in densely packed material. AIChE Conference, Pittsburgh, Oct 28 – Nov 2, 2012.
CP-33 Tracy, B., Byrnes, B., Pingali, K.C. Pharmaceutical applications of nanocomposite layers on drug carriers. AIChE Conference, Pittsburgh, Oct 28 – Nov 2, 2012.
CP-34 Kick, C., Pingali KC. Effect of nanosmearing on the rate of nanostructure formation in individual grains and tablet manufacturing. AIChE Conference, San Francisco, Nov 7, 2013.
CP-35 Pingali KC, Krishnan A, Rajh T, Rozhkova E. Functional groups interaction on PVD coated organic crystals, AIChE Conference, 2017.
CP-36 Chatarla S, Rajh T, Rozhkova E, Pingali KC. Nanosmearing architechture of quantified hydrophilic and hydrophobic groups, AIChE Conference, 2017.
CHEG 3200: Chemical Engineering Thermodynamics
CHEG 3300: Mass Transfer
CHEG 1810: Introduction to Chemical Engineering Computations
CHEG 4870: Senior Design
CHEG 6100: Chemical Engineering Thermodynamics
CHEG 6300: Chemical Reaction Engineering
CHEG 6600: Methods of Research and Engineering Communication
CHEG 7000: Master’s Thesis
CHEG 5950: Pharmaceutical Process and Product Design
2011 – Present: Assistant Professor, Department of Chemical and Paper Engineering, Western Michigan University, Kalamazoo, Michigan, USA.
2009 – 2011: Assistant Research Professor, Department of Chemical & Biochemical Engineering, Rutgers - The State University of New Jersey, USA.
2006 – 2009: Postdoctoral Associate, Department of Chemical & Biochemical Engineering, Rutgers - The State University of New Jersey, USA.
2003 – 2006: Research Associate, Department of Chemical Engineering, New Mexico State University, Las Cruces, USA.
1997-2003: Process Engineer, DuPont Singapore Pte Ltd, Singapore.
1996-1997: Production Officer, Vantech Industries Ltd, Hyderabad, India.
1995-1996: Assistant Engineer, Naturite Agro Products Ltd, Hyderabad, India.
1994-1995: Engineer-Trainee, Armor Polymers Ltd, Boisar, India.
Journal Reviewer for the following scientific research journals
- Chemical Engineering Science
- Journal of Chemical Engineering and Processing
- Journal of Energy and Fuels
- Journal of Environmental Science and Technology
- Journal of Applied Materials and Interfaces
- Journal of Physical Chemical Letters
- Journal of Chemical and Engineering Data
- Journal of Colloid and Interface Science
- Journal of Natural Gas Science and Engineering
- Journal of Pharmaceutical and Biomedical Analysis
- Journal of Industrial and Engineering Chemistry Research
- Journal of Pharmaceutical Innovation
Serving on the ‘Editorial Board’ for the following research journals.
- Journal of Chemical Engineering and Process Techniques
- Journal of Chemical and Process Engineering
Proposal Panelist at the National Science Foundation (NSF)
- NSF Division of Industrial Innovation and Partnerships
o NSF – STTR
- NSF Division of Civil, Mechanical and Manufacturing Innovation (CMMI)
- American Institute of Chemical Engineers
- American Chemical Society
- American Association of Pharmaceutical Scientists
- Session Chair: Currently serving as Session Chair on National Chemical Engineering Conferences.
- Interdisciplinary Initiative: Inter-departmental research activities.
- International Engagement for Student Promotion: Active engagement with international universities for education and research.
- Promoting Diversity and Outreach: Outreach initiative provides fundamental support to high school students in their preparation for college entrance in the STEM fields, particularly chemical engineering involving particulate matter, nanoscience and nanotechnology.
- Invited Speakers: Invited speakers from industry, academia and government to promote education and training.
- Committees at WMU: On faculty selection committee, curriculum committee and thesis committees.
Merit Based Fellowship Award, November 2005
- In recognition of excellent achievement and strong credentials
- Reward for outstanding graduate students who are engaged in the teaching or research mission of New Mexico State University (NMSU)
Outstanding Academic Achievement, December 2004
- In recognition of outstanding academic achievement, maintaining the highest grade point average
Being part of Engineering Research Center (ERC) at Rutgers University, NJ, the following units were developed.
(A) Gravitational Displacement Rheometer for Measuring Flow Properties
(B) Electrostatic Impedance in Powders (Worked with Trek Inc., NY)
- Responsible for development, improvement, testing, measurement, installation, building, performing all the experimental work, develop methodologies, analysis, interpretation of data, writing report, presentation of results, commercialization, performing trial runs, demonstrations, and testing at pharmaceutical company sites.
1. Commercialized (A) at
- Pfizer Inc., Freiburg, Germany.
- Haldor Topsoe, Denmark.
- University of Puerto Rico – Mayaguez.
- Massey University, New Zealand.
2. Commercialized (B) at
- Pfizer Inc.