Biological Sciences
Dr. Brian C. Tripp
Assistant Professor and HTS Coordinator
E-mail: brian.tripp@wmich.edu
Office: 3435 Wood Hall
Lab: 4007 Haenicke Hall
Office Phone: 269 387-4166
Lab phone: 269 387-1955
Visit his personal page: http://homepages.wmich.edu/~btripp/index.htm
Research Description
Area of Research: Enzymology/Protein Engineering/HTS
Assistant Professor of Biological Sciences, Coordinator of the newly developed WMU Molecular Biotechnology program, which has an emphasis on high throughput screening. Dr. Brian Tripp's duties as coordinator of the Molecular Biotechnology program include developing and maintaining interactions with various pharmaceutical companies, mentoring students in this novel program, and coordinating industrial internships. Dr. Tripp's research involves protein engineering and structure-function studies of proteins. He is interested in combinatorial approaches to the investigation and alteration of protein function. He has published on structure-function studies of a gamma-class carbonic anhydrase, in vivo biotinylation of a fusion peptide, and metal-dependent antibody recognition by a flagellin-thioredoxin random peptide library.
Publications
Tripp B.C., Tu C., Ferry, J.G. "Role of Arginine 59 in the gamma-Class Carbonic Anhydrases." Biochemistry. (2002) Jan 15;41(2):669-678.
Tripp B.C., Smith K., Ferry, J.G. "Carbonic anhydrase: new insights for an ancient enzyme." J. Biol. Chem. (2001) Dec 28;276(52):48615-8.
Tripp B.C., Lu Z., Bourque K., Sookdeo H., McCoy J.M. "Investigation of the 'switch-epitope' concept with random peptide libraries displayed as thioredoxin loop fusions." Protein Eng. 2001 May;14(5):367-77.
Tu C., Tripp B.C., Ferry J.G., Silverman D.N. "Bicarbonate as a proton donor in catalysis by Zn(II)- and Co(II)-containing carbonic anhydrases." J. Am.Chem. Soc. (2001) Jun 27;123(25):5861-6.
Tripp B.C., Ferry J.G. "A structure-function study of a proton transport pathway in the gamma-class carbonic anhydrase from Methanosarcina thermophila." Biochemistry. (2000) Aug 8;39(31):9232-40.
Smith P.A., Tripp B.C., DiBlasio-Smith E.A., Lu Z., LaVallie E.R., McCoy J.M. "A plasmid expression system for quantitative in vivo biotinylation of thioredoxin fusion proteins in Escherichia coli." Nucleic Acids Res. (1998) Mar 15;26(6):1414-20.
Lu Z., Tripp B.C., McCoy J.M. "Displaying libraries of conformationally constrained peptides on the surface of Escherichia coli as flagellin fusions." Methods Mol Biol. (1998) 87:265-80.
Tripp, B. C., Kaler, E. W., Sandler, S. I., Kopatsis,
A. "Effect of ionic strength and ionic species on partitioning
behavior of hydrophobic and hydrophilic polystyrene latex beads
in aqueous two-phase polymer systems."
Colloids and Surfaces B-Biointerfaces, (1996) 6(3):151-164.
Tripp, B.C., J.J. Magda, and J.D. Andrade, "Adsorption of Globular-Proteins at the Air/Water Interface as Measured Via Dynamic Surface-Tension - Concentration- Dependence, Mass-Transfer Considerations, and Adsorption- Kinetics." Journal of Colloid and Interface Science (1995) 173(1):16-27.
Lee, C.S., B.C. Tripp, and J.J. Magda, "Does N1 or N2 Control the Onset of Edge Fracture." Rheologica Acta (1992) 31(3):306-308.
Students in Dr. Tripp's laboratory
Jacqueline Kueh - Undergraduate Degree Program
Kyle Kastead - Undergraduate Degree Program