Office: (269) 387-5615
Lab: (269) 387-3849
Office: 3165 Wood Hall, Mail Stop 5410
Lab: 3054 Haenicke Hall
Department of Biological Sciences
Western Michigan University
1903 W Michigan Ave
Kalamazoo MI 49008-5410 USA
Dr. Linn is a neurophysiologist whose interests concern the cellular mechanisms involved in visual processing in the vertebrate retina. A major focus in her lab deals with neuroprotection against glutamate-induced excitotoxicity using an in vitro model of glaucoma. In the in vitro studies, adult pig retinal ganglion cells are isolated from other retinal neurons and cultured under excitotoxic-inducing conditions. Studies in the lab have identified a number of a7 acetylcholine receptor agonists that prevent retinal ganglion cells from dying under excitotoxic conditions. The mechanisms associated with excitotoxicity and neuroprotection against excitotoxocity are analyzed using a combination of pharmacological, immunocytochemical, electrophysiological and ELISA techniques.
In addition to in vitro studies, a rat model of glaucoma has been developed in adult Long Evans rats to analyze the effects of neuroprotective agents on retinal ganglion cell survival under physiological conditions. In this model, glaucoma is induced in one eye of adult rats and potential neuroprotective agents are introduced to the retina to determine if introduction of these agents to the retina prevents the loss of retinal ganglion cells that is normally associated with glaucoma. Other studies are analyzing risk factors associated with the glaucoma-induced condition. Studies from Dr. Linn's lab are funded by the National Institute of Health.
Students in Dr. Linn's laboratory